منابع مشابه
A NEW WORKFLOW OF FETAL DNA PREDICTION FROM CELL-FREE DNA IN MATERNAL PLASMA by
Prediction of fetal DNA allows diagnosing known/passed mutations before child’s birth. Public health significance of such early testing is that it can reassure parents who have negative results and offers timely information for those with abnormal results. My dissertation work presents a new approach of reconstructing fetal DNA from maternal plasma. The method works because plasma from pregnant...
متن کاملCell - free DNA: بیومارکر نوین تشخیص آزمایشگاهی
به انواع مختلف اسیدهای نوکلئیک آزاد در پلاسما شامل قطعات DNA ژنومی،DNA میتوکندریایی، DNA و mRNA های ویروسی و همچنین انواع miRNA اصطلاحا Cell–free nucleic acid گفته می شود. بخش مهمی از این اسیدهای نوکلئیک آزاد در پلاسما را Cell–free DNA (cfDNA) تشکیل می دهد. cfDNA به صورت قطعاتی با وزن مولکولی حدود KB 21-0.18 در سرم یا پلاسمای افراد سالم و افراد مبتلا به بسیاری از بیماری ها قابل تشخیص هستند. ...
متن کاملIntroducing a New and Simple Protocol for Capillary Electrophoresis of Cell Free Fetal Double Stranded DNA
Isolation of cell free fetal DNA (cffDNA) from maternal serum usually leads to very low concentrations of DNA impeding further resolving through conventional methods of electrophoresis. Although several protocols have been described for capillary electrophoresis (CE) of double stranded DNA, they usually need using special polymers or coated capillaries which degrade over time. Herein, we propos...
متن کاملEarly Prediction of Hypertensive Disorders of Pregnancy Using Cell-Free Fetal DNA, Cell-Free Total DNA, and Biochemical Markers.
OBJECTIVE To evaluate the predictive value of separate and combined tests using cell-free fetal DNA (cffDNA), cell-free total DNA (cfDNA), and biochemical markers for the early detection of pregnancies with hypertensive disorders. METHODS A nested case-control study was conducted with 135 singleton pregnancies including 17 gestational hypertension cases, 34 preeclampsia (PE) cases, and 84 con...
متن کاملintroducing a new and simple protocol for capillary electrophoresis of cell free fetal double stranded dna
isolation of cell free fetal dna (cffdna) from maternal serum usually leads to very low concentrations of dna impeding further resolving through conventional methods of electrophoresis. although several protocols have been described for capillary electrophoresis (ce) of double stranded dna, they usually need using special polymers or coated capillaries which degrade over time. herein, we propos...
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ژورنال
عنوان ژورنال: Journal of Clinical Medicine
سال: 2020
ISSN: 2077-0383
DOI: 10.3390/jcm9072307